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(ISBN: 978-0-07-149618-6) Keywords Cocaine Toxicology Source: Drug of abuse Mechanism of Action: CNS stimulant blocks the reuptake of catecholamines: dopamine, norepinephrine & serotonin (DAT, NET & SERT transporters) Na and K channel blocker (at slightly higher doses than those blocking reuptake of catecholamines commonly coadministered with ethanol to create cocaethylene which has a longer half-life (and prolonged high) Symptoms: CNS : Euphoria , which may be followed by anxiety & agitation Psychatric symptoms (including paranoia, psychosis & the sensation of something crawling on the skin or itchy skin) Hyperactivity & Seizures (usually self limiting
Hofstee P, McKeating DR, Bartho LA, Anderson ST, Perkins AV, Cuffe JS (2020) Maternal selenium deficiency in mice alters offspring glucose metabolism and thyroid status in a sexually dimorphic manner
The first instinct for many is to reach for a bottle of ibuprofen
These patients had immune dysfunction and psychosocial stressors that can cause depression
